Gene therapy hope for heart failure patients
Researchers at hospitals in London and Glasgow plan to use an engineered virus to smuggle DNA into the heart in the first ever clinical trial of "gene therapy" for heart failure. Our goal is to fight back against heart failure by targeting and reversing some of the critical molecular changes arising in the heart when it fails. Alex Lyon, cardiologist The technique, which has been 20 years in development, could help the 750,000 people in the UK living with heart failure. The condition results from damage to the heart left over from a heart attack or side-effects of powerful chemotherapy drugs. After the heart is starved of oxygen, cells die and the remaining heart cells become fatigued. "Once heart failure starts, it progresses into a vicious cycle where the pumping becomes weaker and weaker, as each heart cell simply cannot respond to the increased demand." said Alex Lyon, a cardiologist at the Royal Brompton hospital in London who is leading the trial in...